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It is important for you to take your medicine every day as directed by your doctor. If you stop taking COREG CR suddenly, you could have chest pain and a heart attack. If your doctor decides that you should stop taking COREG CR, your doctor may slowly lower your dose over time before stopping it completely.

COREG CR is not approved for use in children under 18 years of age.

Do not take COREG CR if you:

• have severe heart failure and require certain intravenous medicines that help support circulation.
• have asthma or other breathing problems.
• have a slow heartbeat or certain conditions that cause your heart to skip a beat (irregular heartbeat).
• have liver problems.
• are allergic to any of the ingredients in COREG CR. See "What are the ingredients in COREG CR?"

Tell your doctor about all of your medical conditions, including if you:

• have asthma or other lung problems (such as bronchitis or emphysema).
• have problems with blood flow in your feet and legs (peripheral vascular disease). COREG CR can make some of your symptoms worse.
• have diabetes.
• have thyroid problems.
• have a condition called pheochromocytoma.
• have had severe allergic reactions.
• are scheduled for surgery and will be given anesthetic agents.
• are pregnant or trying to become pregnant. It is not known if COREG CR is safe for your unborn baby. You and your doctor should talk about the best way to control your high blood pressure during pregnancy.
• are breastfeeding. It is not known if COREG CR passes into your breast milk. You should not breastfeed while using COREG CR.

Tell your doctor about all of the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. COREG CR and certain other medicines can affect each other and cause serious side effects. COREG CR may affect the way other medicines work. Also, other medicines may affect how well COREG CR works.

COREG CR can cause you to feel dizzy, tired, or faint. Do not drive a car, use machinery, or do anything that needs you to be alert if you have these symptoms.

Serious side effects of COREG CR include:

• chest pain and heart attack if you suddenly stop taking COREG CR. See "What is the most important information I should know about COREG CR?"
• slow heart beat.
• low blood pressure (which may cause dizziness or fainting when you stand up). If these happen, sit or lie down, and tell your doctor right away.
• worsening heart failure. Tell your doctor right away if you have signs and symptoms that your heart failure may be worse, such as weight gain or increased shortness of breath.
• changes in your blood sugar. If you have diabetes, tell your doctor if you have any changes in your blood sugar levels.
• masking (hiding) the symptoms of low blood sugar, especially a fast heartbeat.
• new or worsening symptoms of peripheral vascular disease.
  • leg pain that happens when you walk, but goes away when you rest
  • no feeling (numbness) in your legs or feet while you are resting
  • cold legs or feet
• masking the symptoms of hyperthyroidism (overactive thyroid), such as a fast heartbeat.
• worsening of severe allergic reactions. Medicines to treat a severe allergic reaction may not work as well while you are taking COREG CR.
• rare but serious allergic reactions (including hives or swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing) have happened in patients who were on COREG or COREG CR. These reactions can be life-threatening. In some cases, these reactions happened in patients who had been on COREG before taking COREG CR.

Common side effects of COREG CR include shortness of breath, weight gain, diarrhea, and tiredness. If you wear contact lenses, you may have fewer tears or dry eyes that can become bothersome.

Call your doctor if you have any side effects that bother you or don’t go away.